Deep insights into Mecp2-driven transcriptional (de)regulation at embryonic developmental stage through RNA-Seq data analysis

Authors

  • Kumar Parijat Tripathi Genomic, Proteomic and Transcriptomic Laboratory, National Research Council of Italy (CNR), Institute for High-Performance Computing and Networking (ICAR), Napoli
  • Maurizio D'Esposito Institute of Genetics and Biophysics - ABT, Napoli
  • Mario R Guarracino Genomic, Proteomic and Transcriptomic Laboratory, National Research Council of Italy (CNR), Institute for High-Performance Computing and Networking (ICAR), Napoli
  • Marcella Vacca Institute of Genetics and Biophysics - ABT, Napoli

DOI:

https://doi.org/10.14806/ej.21.A.816

Keywords:

Mecp2, Tophat2, Cufflinks, QuickGO, DAVID, web-services, Python

Abstract

Rett Syndrome (RTT, MIM 312750) is a progressive X-linked neurodevelopmental disorder due to mutation of the Mecp2 gene (encoding the transcription regulator methyl-CpG binding protein 2). To understand the biological mechanism behind transcriptional remodeling under the influence of Mecp2 knocking out, we need large-scale study of the transcriptional response of null cortical neurons before and after treatment with serotonin receptor stimulator.

Author Biographies

  • Kumar Parijat Tripathi, Genomic, Proteomic and Transcriptomic Laboratory, National Research Council of Italy (CNR), Institute for High-Performance Computing and Networking (ICAR), Napoli

    Graduate fellow,

    Ricerca Assegnista

    Genomic, Proteomic and Transcriptomic Laboratory
    National Research Council of Italy (CNR)
    Institute for High-Performance Computing and Networking (ICAR)

  • Maurizio D'Esposito, Institute of Genetics and Biophysics - ABT, Napoli

    CNR RESEARCHER

    Institute of Genetics and Biophysics - ABT

     

  • Mario R Guarracino, Genomic, Proteomic and Transcriptomic Laboratory, National Research Council of Italy (CNR), Institute for High-Performance Computing and Networking (ICAR), Napoli
    CNR RESEARCHER
  • Marcella Vacca, Institute of Genetics and Biophysics - ABT, Napoli
    researcher
EJ 21.A

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Published

2015-03-25

Issue

Vol. 21: Supplement A

Section

Oral Presentations

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