Exosomics

Authors

  • Thanasis Mitsis Laboratory of Genetics, Department of Biotechnology, School of Applied Biology & Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855 Athens
  • Katerina Pierouli Laboratory of Genetics, Department of Biotechnology, School of Applied Biology & Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855 Athens
  • Kalliopi Io Diakou Laboratory of Genetics, Department of Biotechnology, School of Applied Biology & Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855 Athens
  • Eleni Papakonstantinou Laboratory of Genetics, Department of Biotechnology, School of Applied Biology & Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855 Athens
  • Flora Bacopoulou University Research Institute of Maternal and Child Health & Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, “Aghia Sophia” Children's Hospital, 11527 Athens
  • George P Chrousos University Research Institute of Maternal and Child Health & Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, “Aghia Sophia” Children's Hospital, 11527 Athens Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece
  • Dimitrios Vlachakis Laboratory of Genetics, Department of Biotechnology, School of Applied Biology & Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855 Athens University Research Institute of Maternal and Child Health & Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, “Aghia Sophia” Children's Hospital, 11527 Athens, Greece Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece

DOI:

https://doi.org/10.14806/ej.26.0.934

Keywords:

Extracellular Vesicles, Exosomes, Medical Applications

Abstract

Extracellular vesicles have been the focus of a large number of studies in the past five years. Exosomes, a subgroup of extracellular vesicles, are of particularly high interest because they partake in a wide number of biological pathways.  Produced by a variety of cells, exosomes have an important role in both physiological and pathological conditions.  Exosome cargo heavily defines the vesicles' unique characteristics, and cargo with the most intriguing prospects in its' biomedical applications is the non-coding RNAs.  Non-coding RNAs, and specifically microRNAs are implicated in the regulation of many biological processes and have been associated with numerous diseases. Exosomes containing such important cargo can be used as biomarkers, therapeutic biomaterials, or even drug carriers. The potential media use of exosomes seems promising. However, some obstacles should be overcome before their clinical application.  Synthetic exosome-like biomolecules may be a solution, but their production is still in their beginning stages. This review provides concise information regarding the current trends in exosome studies.

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Published

2020-08-04

Issue

Vol. 26

Section

Reviews

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