Josef Finsterer


The etiology of polycystic ovary syndrome (PCOS) is not exactly known, but there are indications that genetic factors, exposure to androgen in early childhood, and obesity lead to a disruption of the hypothalamic-pituitary-ovarian axis and dysregulation of microRNAs. Chromosomal aberrations have rarely been described as a cause of PCOS. We present the case of a 20-year-old female diagnosed with PCOS at age 17 due to hyperandrogenism, obesity, polycystic ovaries, amenorrhoea, and emerging insulin resistance. A work-up for the cause of PCOS revealed a previously undescribed translocation 46XX t(2;9)(q21;p24). Alternative causes of PCOS were excluded. In addition, the patient had post-COVID syndrome. The patient was treated with contraceptive pills. PCOS can be caused by the translocation 46XX t(2;9)(q21;p24). The clinical manifestations of PCOS can be exacerbated by post-COVID syndrome.



PCOS, 46XX t(2, 9)(q21, p24), post-COVID, metabolic disease, hyper-androgenism

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How to Cite
Polycystic ovary syndrome due to the novel translocation 46XX t(2;9)(q21;p24). (2023). Archive of Clinical Cases, 10(3), Arch Clin Cases. 2023;10(3):123-124.
Case Reports

How to Cite

Polycystic ovary syndrome due to the novel translocation 46XX t(2;9)(q21;p24). (2023). Archive of Clinical Cases, 10(3), Arch Clin Cases. 2023;10(3):123-124.